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Heme oxygenase 1 variations and lung function decline in smokers: proof of replication
  1. M Siedlinski1,
  2. C C van Diemen1,
  3. D S Postma2,
  4. H M Boezen1
  1. 1
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands
  2. 2
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, the Netherlands
  1. Dr H M Boezen, Department of Epidemiology, University Medical Center Groningen, E3.29, PO Box 30.001, 9700 RB Groningen, The Netherlands; H.M.Boezen{at}epi.umcg.nl

https://doi.org/10.1136/jmg.2008.058123

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    We provide supportive evidence for a role of the promoter polymorphism (GT-repeat) in heme oxygenase 1 (HO-1) in relation to lung function loss over time. This observation has been made by Guénégou and colleagues in a Caucasian population, and a call for replication of these results in a larger and independent cohort was made.1 The relevance of HO-1 has been widely acknowledged.2 Chronic obstructive pulmonary disease (COPD)—often a consequence of abnormally accelerated lung function decline3—has been widely studied in relation to HO-1 promoter GT-repeat, using a …

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    Footnotes

    • Competing interests: None.

    • Funding: Dutch Asthma Foundation (grant 3.2.02.51), The Netherlands; University of Groningen, the Netherlands.