Article Text

PDF
Heme oxygenase 1 variations and lung function decline in smokers: proof of replication
  1. M Siedlinski1,
  2. C C van Diemen1,
  3. D S Postma2,
  4. H M Boezen1
  1. 1
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands
  2. 2
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, the Netherlands
  1. Dr H M Boezen, Department of Epidemiology, University Medical Center Groningen, E3.29, PO Box 30.001, 9700 RB Groningen, The Netherlands; H.M.Boezen{at}epi.umcg.nl

Statistics from Altmetric.com

We provide supportive evidence for a role of the promoter polymorphism (GT-repeat) in heme oxygenase 1 (HO-1) in relation to lung function loss over time. This observation has been made by Guénégou and colleagues in a Caucasian population, and a call for replication of these results in a larger and independent cohort was made.1 The relevance of HO-1 has been widely acknowledged.2 Chronic obstructive pulmonary disease (COPD)—often a consequence of abnormally accelerated lung function decline3—has been widely studied in relation to HO-1 promoter GT-repeat, using a …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.