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Family size limitation: a method for demonstrating recessive inheritance.
  1. J F Brookfield,
  2. R J Pollitt,
  3. I D Young
  1. Department of Genetics, University of Leicester.

    Abstract

    Limitation of family size after the birth of a child with a serious disorder poses a problem in demonstrating autosomal recessive inheritance. In this paper methods are presented for distinguishing autosomal recessive inheritance given a 100% deterrent effect, and revealing a partial deterrent effect by analysis of sibship size and comparison with general population data. These methods are illustrated using information from phenylketonuria families.

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