Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene,
encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary …

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility
loci, but these explain only a small fraction of the familial risk of the disease. Five of these …

To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

Despite intensive efforts using linkage and candidate gene approaches, the genetic etiology
for the majority of families with a multi-generational breast cancer predisposition is unknown …

Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We
investigated breast cancer risk associations of eight susceptibility loci identified in GWAS …

RAD51 colocalizes with both BRCA1 and BRCA2, and genetic variants in RAD51 would be
candidate BRCA1/2 modifiers. We searched for RAD51 polymorphisms by sequencing 20 …

Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue
organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers …

Numerous genetic factors that influence breast cancer risk are known. However,
approximately two-thirds of the overall familial risk remain unexplained. To determine …

The considerable uncertainty regarding cancer risks associated with inherited mutations of
BRCA2 is due to unknown factors. To investigate whether common genetic variants modify …