Background To identify the strategies and contextual factors that enable optimal
engagement of patients in the design, delivery, and evaluation of health services. Methods …

In 1995, the American Society of Human Genetics (ASHG) and American College of Medical
Genetics and Genomics (ACMG) jointly published a statement on genetic testing in children …

With CRISPR/Cas9 and other genome-editing technologies, successful somatic and
germline genome editing are becoming feasible. To respond, an American Society of …

This paper contains a joint ESHG/ASHG position document with recommendations
regarding responsible innovation in prenatal screening with non-invasive prenatal testing …

The evidence base supporting genetic and genomic sequence-variant interpretations is
continuously evolving. An inherent consequence is that a variant's clinical significance might …

Genetic discrimination (GD) is a complex, multifaceted ethical, psychosocial, and legal
phenomenon. It is defined as the differential treatment of asymptomatic individuals or their …

Exome sequencing and genome sequencing have the potential to improve clinical utility for
patients undergoing genetic investigations. However, evidence of clinical utility is limited to …

Objective To assess the nature and prevalence of genetic discrimination experienced by
people at risk for Huntington's disease who had undergone genetic testing or remained …

Despite a growing consensus that ethical and social values should be addressed in health
technology assessment (HTA) processes, there exist a variety of methods for doing so …

This study systematically reviewed and synthesized the literature on psychological and
clinical outcomes of receiving a variant of uncertain significance (VUS) from multigene panel …