User profiles for "author:Yoon Shin Cho"

Yoon Shin Cho

Hallym University Biomedical Science Professor
Verified email at hallym.ac.kr
Cited by 21050

Biological, clinical and population relevance of 95 loci for blood lipids

TM Teslovich, K Musunuru, AV Smith, AC Edmondson… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

YS Cho, MJ Go, YJ Kim, JY Heo, JH Oh, HJ Ban… - Nature …, 2009 - nature.com
To identify genetic factors influencing quantitative traits of biomedical importance, we
conducted a genome-wide association study in 8,842 samples from population-based …

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

CKDGen Consortium, KidneyGen Consortium… - Nature, 2011 - nature.com
Blood pressure is a heritable trait influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥ 140 mm …

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

MCY Ng, KS Park, B Oh, CHT Tam, YM Cho… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Recent genome-wide association studies have identified six novel genes for
type 2 diabetes and obesity and confirmed TCF7L2 as the major type 2 diabetes gene to …

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

YS Cho, CH Chen, C Hu, J Long, RT Hee Ong, X Sim… - Nature …, 2012 - nature.com
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes
(T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D …

Identification of type 2 diabetes loci in 433,540 East Asian individuals

CN Spracklen, M Horikoshi, YJ Kim, K Lin, F Bragg… - Nature, 2020 - nature.com
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

N Kato, F Takeuchi, Y Tabara, TN Kelly, MJ Go, X Sim… - Nature …, 2011 - nature.com
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and
diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP …

Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits

YJ Kim, MJ Go, C Hu, CB Hong, YK Kim, JY Lee… - Nature …, 2011 - nature.com
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis
combining Korean genome-wide association results from the KARE project (n= 8,842) and …

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

J Flannick, G Thorleifsson, NL Beer, SBR Jacobs… - Nature …, 2014 - nature.com
Loss-of-function mutations protective against human disease provide in vivo validation of
therapeutic targets,,, but none have yet been described for type 2 diabetes (T2D). Through …

A genome-wide association study of gestational diabetes mellitus in Korean women

SH Kwak, SH Kim, YM Cho, MJ Go, YS Cho… - Diabetes, 2012 - Am Diabetes Assoc
Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still
limited. In this study, we performed a two-stage genome-wide association analysis in Korean …