Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF
M Lv, W Liu, W Chi, X Ni, J Wang, H Cheng… - Journal of medical …, 2020 - jmg.bmj.com
Background Asthenoteratospermia, one of the most common causes for male infertility, often
presents with defective sperm heads and/or flagella. Multiple morphological abnormalities of …
presents with defective sperm heads and/or flagella. Multiple morphological abnormalities of …
[HTML][HTML] NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation
M Sun, M Jia, H Ren, B Yang, W Chi, G Xin… - Nature …, 2021 - nature.com
A functional mitotic spindle is essential for accurate chromosome congression and
segregation during cell proliferation; however, the underlying mechanisms of its assembly …
segregation during cell proliferation; however, the underlying mechanisms of its assembly …
[HTML][HTML] GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis
The primary cilium, which disassembles before mitotic entry and reassembles after mitosis,
organizes many signal transduction pathways that are crucial for cell life and individual …
organizes many signal transduction pathways that are crucial for cell life and individual …
[HTML][HTML] DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6
Centrosome number is tightly controlled during the cell cycle to ensure proper spindle
assembly and cell division. However, the underlying mechanism that controls centrosome …
assembly and cell division. However, the underlying mechanism that controls centrosome …
[HTML][HTML] PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations
W Chi, G Wang, G Xin, Q Jiang, C Zhang - Journal of Cell Biology, 2021 - rupress.org
Centrosome duplication occurs under strict spatiotemporal regulation once per cell cycle,
and it begins with cartwheel assembly and daughter centriole biogenesis at the lateral sites …
and it begins with cartwheel assembly and daughter centriole biogenesis at the lateral sites …
Sufu negatively regulates both initiations of centrosome duplication and DNA replication
T Zhuang, B Zhang, Y Song, F Huang… - Proceedings of the …, 2021 - National Acad Sciences
Centrosome duplication and DNA replication are two pivotal events that higher eukaryotic
cells use to initiate proliferation. While DNA replication is initiated through origin licensing …
cells use to initiate proliferation. While DNA replication is initiated through origin licensing …