[HTML][HTML] Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

M Dominguez-Valentin, JR Sampson, TT Seppälä… - Genetics in …, 2020 - nature.com
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …

[PDF][PDF] Benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three European expert centers

H Vasen, I Ibrahim, CG Ponce, EP Slater… - Journal of Clinical …, 2016 - llusurgonc.org
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Hereditary
factors play a role in the development of PDAC in 3% to 5% of all patients. Surveillance of …

[HTML][HTML] Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

T Seppälä, K Pylvänäinen, DG Evans… - Hereditary cancer in …, 2017 - Springer
Background We have previously reported a high incidence of colorectal cancer (CRC) in
carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy …

[HTML][HTML] Possible Value of Faecal Immunochemical Test (FIT) When Added in Symptomatic Patients Referred for Colonoscopy: A Systematic Review

HJ Brands, B Van Dijk, RM Brohet, HL van Westreenen… - Cancers, 2023 - mdpi.com
Simple Summary Literature has shown that the correlation between intestinal complaints
and the gain of colonoscopy regarding colorectal cancer (CRC) is poor. Adding a faecal …

Variation in precursor lesions of pancreatic cancer among high-risk groups

TP Potjer, I Schot, P Langer, JT Heverhagen… - Clinical cancer …, 2013 - AACR
Purpose: Pancreatic ductal adenocarcinoma (PDAC) surveillance programs are currently
offered to high-risk individuals aiming to detect precursor lesions or PDAC at an early stage …

Colorectal surveillance in Lynch syndrome families

WH de Vos tot Nederveen Cappel, HJ Järvinen… - Familial cancer, 2013 - Springer
Lynch syndrome (LS) is an autosomal dominant disorder caused by a mutation in one of the
mismatch repair genes. Mutation carriers have a life-time risk of developing colorectal …

Surveillance for hereditary nonpolyposis colorectal cancer

WH de Vos tot Nederveen Cappel… - Diseases of the colon & …, 2002 - Springer
Hereditary nonpolyposis colorectal cancer is caused by germline mutations in DNA
mismatch repair genes. Mutation carriers have a 60 to 85 percent risk of developing …

[HTML][HTML] Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch …

M Dominguez-Valentin, EJ Crosbie, C Engel… - Genetics in …, 2021 - nature.com
Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-
oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of …

[HTML][HTML] Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome …

TT Seppälä, A Ahadova, M Dominguez-Valentin… - Hereditary cancer in …, 2019 - Springer
Background Recent epidemiological evidence shows that colorectal cancer (CRC)
continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite …

[HTML][HTML] Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for resection of large distal non-pedunculated colorectal adenomas …

Y Backes, LMG Moons, JD Van Bergeijk, L Berk… - BMC …, 2016 - Springer
Background Endoscopic mucosal resection (EMR) is currently the most used technique for
resection of large distal colorectal polyps. However, in large lesions EMR can often only be …