[HTML][HTML] Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
[PDF][PDF] Benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three European expert centers
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Hereditary
factors play a role in the development of PDAC in 3% to 5% of all patients. Surveillance of …
factors play a role in the development of PDAC in 3% to 5% of all patients. Surveillance of …
[HTML][HTML] Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
Background We have previously reported a high incidence of colorectal cancer (CRC) in
carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy …
carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy …
[HTML][HTML] Possible Value of Faecal Immunochemical Test (FIT) When Added in Symptomatic Patients Referred for Colonoscopy: A Systematic Review
HJ Brands, B Van Dijk, RM Brohet, HL van Westreenen… - Cancers, 2023 - mdpi.com
Simple Summary Literature has shown that the correlation between intestinal complaints
and the gain of colonoscopy regarding colorectal cancer (CRC) is poor. Adding a faecal …
and the gain of colonoscopy regarding colorectal cancer (CRC) is poor. Adding a faecal …
Variation in precursor lesions of pancreatic cancer among high-risk groups
TP Potjer, I Schot, P Langer, JT Heverhagen… - Clinical cancer …, 2013 - AACR
Purpose: Pancreatic ductal adenocarcinoma (PDAC) surveillance programs are currently
offered to high-risk individuals aiming to detect precursor lesions or PDAC at an early stage …
offered to high-risk individuals aiming to detect precursor lesions or PDAC at an early stage …
Colorectal surveillance in Lynch syndrome families
WH de Vos tot Nederveen Cappel, HJ Järvinen… - Familial cancer, 2013 - Springer
Lynch syndrome (LS) is an autosomal dominant disorder caused by a mutation in one of the
mismatch repair genes. Mutation carriers have a life-time risk of developing colorectal …
mismatch repair genes. Mutation carriers have a life-time risk of developing colorectal …
Surveillance for hereditary nonpolyposis colorectal cancer
WH de Vos tot Nederveen Cappel… - Diseases of the colon & …, 2002 - Springer
Hereditary nonpolyposis colorectal cancer is caused by germline mutations in DNA
mismatch repair genes. Mutation carriers have a 60 to 85 percent risk of developing …
mismatch repair genes. Mutation carriers have a 60 to 85 percent risk of developing …
[HTML][HTML] Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch …
M Dominguez-Valentin, EJ Crosbie, C Engel… - Genetics in …, 2021 - nature.com
Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-
oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of …
oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of …
[HTML][HTML] Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome …
Background Recent epidemiological evidence shows that colorectal cancer (CRC)
continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite …
continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite …
[HTML][HTML] Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for resection of large distal non-pedunculated colorectal adenomas …
Y Backes, LMG Moons, JD Van Bergeijk, L Berk… - BMC …, 2016 - Springer
Background Endoscopic mucosal resection (EMR) is currently the most used technique for
resection of large distal colorectal polyps. However, in large lesions EMR can often only be …
resection of large distal colorectal polyps. However, in large lesions EMR can often only be …