Vincenzo Sorrentino and Pompeo Volpe review some recent deve~ o~ menis~ the
ryanodine receptor channels have now been found to be expressed in the central nervous …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

Background—Catecholaminergic polymorphic ventricular tachycardia is a genetic
arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular …

Mitochondrial stress requires timely intervention to prevent mitochondrial and cellular
dysfunction. Re-establishing the correct protein homeostasis is crucial for coping with …

Ryanodine receptors (RyRs) are intracellular calcium release channels that participate in
controlling cytosolic calcium levels. At variance with the probably ubiquitous inositol 1, 4, 5 …

Alzheimer's disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …

Neuromuscular diseases are often caused by inherited mutations that lead to progressive
skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice …

The growth arrest-specific gas5 gene was isolated from mouse genomic DNA and
structurally characterized. The transcriptional unit is divided into 12 exons that span around …

In contrast to the preponderance of affected males in families with X-linked mental
retardation, Rett syndrome (RTT) is a neurological disorder occurring almost exclusively in …

Assembly of specialized membrane domains, both of the plasma membrane and of the ER,
is necessary for the physiological activity of striated muscle cells. The mechanisms that …