Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

Hereditary diffuse gastric cancer (HDGC) is the only known cancer syndrome that is
dominated by gastric adenocarcinoma. HDGC is caused by germline mutation of the CDH1 …

25–30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline
mutations of the CDH1 (E-cadherin) gene. In light of new data and advancement of …

Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome defined by germline
mutation of the E-cadherin gene (CDH-1). The cumulative risk for advanced gastric cancer in …

The importance of loss of the cell-cell adhesion molecule E-cadherin (encoded by CDH1) to
tumor progression is well established. However, CDH1 germ-line mutations predispose to …

The initial development of diffuse gastric cancer (DGC) is poorly understood. The study of E-
cadherin (CDH1) germ line mutation carriers predisposed to DGC provides a rare …

Hereditary diffuse gastric cancer (HDGC) is the only known predisposition syndrome
dominated by carcinoma of the stomach and with a recognised genetic cause. Germline …

The Bonapartes are probably the most notorious reported gastric cancer family. However,
recent analysis of Napoleon's family history and pathology records challenges the …

Persisting ethnic disparities in cancer incidence and outcomes exist between M āori and
non‐M āori in A otearoa/N ew Z ealand. It is difficult to disentangle the complex interplay of …