To better understand the relationship between tumor-host interactions and the efficacy of
chemotherapy, we have developed an analytical approach to quantify several biological …

Introduction: Ovarian cancer is mostly diagnosed at advanced stage. Better survival is
achieved through complete debulking surgery and chemotherapy. Historically, neoadjuvant …

Background We have previously described gene-expression signatures that predict growth
inhibitory and cytotoxic effects of common chemotherapeutic drugs in vitro. The aim of this …

Specific human papillomavirus genotypes are associated with most ano‐genital carcinomas
and a large subset of oro‐pharyngeal carcinomas. Human papillomavirus DNA is thus a …

Background TP53 has a crucial role in the DNA damage response. We therefore tested the
hypothesis that taxanes confer a greater advantage than do anthracyclines on breast …

To ensure their high proliferation rate, tumor cells have an iron metabolic disorder causing
them to have increased iron needs, making them more susceptible to iron deprivation. This …

It has recently been shown that the risk of a rare subtype of endometrial carcinoma (serous
type) in women carrying a germline BRCA1/2 pathogenic variant is increased. We assessed …

The treatment of epithelial ovarian cancer (EOC) is narrowly focused despite the
heterogeneity of this disease in which outcomes remain poor. To stratify EOC patients for …

BRCA1 and BRCA2 are tumour suppressor genes that have been characterised as
predisposition genes for the development of hereditary breast and ovarian cancers among …

Flat epithelial atypia (FEA) is a borderline lesion that might represent an early stage in the
development of certain low-grade carcinomas in situ and invasive cancers. There are no …