User profiles for "author:U-S Khoo"
Ui Soon KhooThe University of Hong Kong Verified email at pathology.hku.hk Cited by 6393 |
[HTML][HTML] DC-SIGN and L-SIGN: the SIGNs for infection
Two closely related trans-membrane C-type lectins dendritic cell-specific intracellular
adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN or CD209) and liver/lymph …
adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN or CD209) and liver/lymph …
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
CCL Wong, DM Gilkes, H Zhang… - Proceedings of the …, 2011 - National Acad Sciences
Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to
colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia …
colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia …
[HTML][HTML] Androgen receptor as an emerging feasible biomarker for breast cancer
CP You, MH Leung, WC Tsang, US Khoo, H Tsoi - Biomolecules, 2022 - mdpi.com
Biomarkers can be used for diagnosis, prognosis, and prediction in targeted therapy. The
estrogen receptor α (ERα) and human epidermal growth factor receptor 2 (HER2) are …
estrogen receptor α (ERα) and human epidermal growth factor receptor 2 (HER2) are …
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32. 1, 5q14. 3 and 15q26. 1
In a three-stage genome-wide association study among East Asian women including 22,780
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …
[HTML][HTML] Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance
P Khongkow, AR Gomes, C Gong, EPS Man… - Oncogene, 2016 - nature.com
FOXM1 has been implicated in taxane resistance, but the molecular mechanism involved
remains elusive. In here, we show that FOXM1 depletion can sensitize breast cancer cells …
remains elusive. In here, we show that FOXM1 depletion can sensitize breast cancer cells …
[HTML][HTML] Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer
Genetic factors play an important role in the etiology of both sporadic and familial breast
cancer. We aimed to discover novel genetic susceptibility loci for breast cancer. We …
cancer. We aimed to discover novel genetic susceptibility loci for breast cancer. We …
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
M Khongkow, Y Olmos, C Gong, AR Gomes… - …, 2013 - academic.oup.com
In this study, we report the identification of a novel role of SIRT6 in both epirubicin and
paclitaxel resistance in breast cancer. We found that SIRT6 protein levels are elevated in …
paclitaxel resistance in breast cancer. We found that SIRT6 protein levels are elevated in …
FOXO3a represses VEGF expression through FOXM1-dependent and-independent mechanisms in breast cancer
CT Karadedou, AR Gomes, J Chen, M Petkovic, KK Ho… - Oncogene, 2012 - nature.com
Vascular endothelial growth factor (VEGF) has a central role in breast cancer development
and progression, but the mechanisms that control its expression are poorly understood …
and progression, but the mechanisms that control its expression are poorly understood …
[HTML][HTML] Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
Severe acute respiratory syndrome (SARS) is caused by infection of a previously
undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is …
undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is …
[HTML][HTML] Modulating the activity of androgen receptor for treating breast cancer
CP You, H Tsoi, EPS Man, MH Leung… - International Journal of …, 2022 - mdpi.com
The androgen receptor (AR) is a steroid hormone receptor widely detected in breast cancer.
Evidence suggests that the AR might be a tumor suppressor in estrogen receptor alpha …
Evidence suggests that the AR might be a tumor suppressor in estrogen receptor alpha …