User profiles for "author:U-S Khoo"

Ui Soon Khoo

The University of Hong Kong
Verified email at pathology.hku.hk
Cited by 6393

[HTML][HTML] DC-SIGN and L-SIGN: the SIGNs for infection

US Khoo, KYK Chan, VSF Chan, CLS Lin - Journal of molecular medicine, 2008 - Springer
Two closely related trans-membrane C-type lectins dendritic cell-specific intracellular
adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN or CD209) and liver/lymph …

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

CCL Wong, DM Gilkes, H Zhang… - Proceedings of the …, 2011 - National Acad Sciences
Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to
colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia …

[HTML][HTML] Androgen receptor as an emerging feasible biomarker for breast cancer

CP You, MH Leung, WC Tsang, US Khoo, H Tsoi - Biomolecules, 2022 - mdpi.com
Biomarkers can be used for diagnosis, prognosis, and prediction in targeted therapy. The
estrogen receptor α (ERα) and human epidermal growth factor receptor 2 (HER2) are …

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32. 1, 5q14. 3 and 15q26. 1

Q Cai, B Zhang, H Sung, SK Low, SS Kweon, W Lu… - Nature …, 2014 - nature.com
In a three-stage genome-wide association study among East Asian women including 22,780
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …

[HTML][HTML] Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

P Khongkow, AR Gomes, C Gong, EPS Man… - Oncogene, 2016 - nature.com
FOXM1 has been implicated in taxane resistance, but the molecular mechanism involved
remains elusive. In here, we show that FOXM1 depletion can sensitize breast cancer cells …

[HTML][HTML] Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer

J Long, Q Cai, H Sung, J Shi, B Zhang, JY Choi… - PLoS …, 2012 - journals.plos.org
Genetic factors play an important role in the etiology of both sporadic and familial breast
cancer. We aimed to discover novel genetic susceptibility loci for breast cancer. We …

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer

M Khongkow, Y Olmos, C Gong, AR Gomes… - …, 2013 - academic.oup.com
In this study, we report the identification of a novel role of SIRT6 in both epirubicin and
paclitaxel resistance in breast cancer. We found that SIRT6 protein levels are elevated in …

FOXO3a represses VEGF expression through FOXM1-dependent and-independent mechanisms in breast cancer

CT Karadedou, AR Gomes, J Chen, M Petkovic, KK Ho… - Oncogene, 2012 - nature.com
Vascular endothelial growth factor (VEGF) has a central role in breast cancer development
and progression, but the mechanisms that control its expression are poorly understood …

[HTML][HTML] Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

VSF Chan, KYK Chan, Y Chen, LLM Poon… - Nature …, 2006 - nature.com
Severe acute respiratory syndrome (SARS) is caused by infection of a previously
undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is …

[HTML][HTML] Modulating the activity of androgen receptor for treating breast cancer

CP You, H Tsoi, EPS Man, MH Leung… - International Journal of …, 2022 - mdpi.com
The androgen receptor (AR) is a steroid hormone receptor widely detected in breast cancer.
Evidence suggests that the AR might be a tumor suppressor in estrogen receptor alpha …