Wolfram syndrome (WS) is the inherited association of juvenile‐onset insulin‐dependant
diabetes mellitus and progressive bilateral optic atrophy. A nuclear gene, WFS1/wolframin …

Adrenarche reflects the maturation of the adrenal zona reticularis resulting in increased
secretion of the adrenal androgen precursor DHEA and its sulphate ester DHEAS …

Summary Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transporter, the gene
of which is located on the X chromosome. We tested whether mutations in MCT8 cause …

Wolfram syndrome is the association of diabetes mellitus and optic atrophy, and is
sometimes called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and …

Type 2 diabetes mellitus is caused by a combination of insulin resistance and β cell failure.
The polygenic nature of type 2 diabetes has made it difficult to study. Although many …

OBJECTIVE—To estimate the incidence of type 2 diabetes in children< 17 years of age and
to investigate the relationship of diabetes with increasing childhood obesity in the UK and …

Wolcott-Rallison syndrome (WRS) is a rare autosomal-recessive disorder characterized by
the association of permanent neonatal or early-infancy insulin-dependent diabetes, multiple …

OBJECTIVE To explore the prevalence of lipid abnormalities and their relationship with
albumin excretion and microalbuminuria in adolescents with type 1 diabetes. RESEARCH …

Wolfram syndrome, an autosomal recessive disorder characterized by diabetes mellitus and
optic atrophy, is caused by mutations in the WFS1 gene encoding an endoplasmic reticulum …

Aims/hypotheses In adults, type 2 diabetes and obesity have been associated with structural
brain changes, even in the absence of dementia. Some evidence suggested similar …