Familial adenomatous polyposis (FAP) is an inherited disorder that represents the most
common gastrointestinal polyposis syndrome. Germline mutations in the APC gene were …

Purpose Colorectal cancer is an important cause of mortality in the developed world.
Hereditary forms are due to germ-line mutations in APC, MUTYH, and the mismatch repair …

Colorectal cancer (CRC) is one of the most frequent neoplasms and an important cause of
mortality in the developed world. This cancer is caused by both genetic and environmental …

Purpose: Early-onset colorectal cancer (CRC) is suggestive of a hereditary predisposition.
Lynch syndrome is the most frequent CRC hereditary cause. The MUTYH gene has also …

Colorectal cancer (CRC) is one of the most common neoplasms in the world. Fanconi
anemia (FA) is a very rare genetic disease causing bone marrow failure, congenital growth …

BACKGROUND Colorectal cancers (CRCs) that have microsatellite instability (MSI) and
mutL homolog 1 (MLH1) immunoloss are observed in 3 clinical scenarios: Lynch syndrome …

Serrated polyposis syndrome (SPS) is a recently recognised high risk condition for
colorectal cancer (CRC) characterised by the presence of large and/or multiple serrated …

Background & Aims Colonoscopy reduces colorectal cancer (CRC) incidence and mortality
in Lynch syndrome (LS) carriers. However, a high incidence of postcolonoscopy CRC …

Background Colorectal cancer (CRC) multiplicity has been mainly related to polyposis and
non-polyposis hereditary syndromes. In sporadic CRC, aberrant gene promoter methylation …

Background & Aims Dye-based pancolonic chromoendoscopy is recommended for
colorectal cancer surveillance in patients with Lynch syndrome. However, there is scarce …