Given the unique biological requirements of sound transduction and the selective advantage
conferred upon a species capable of sensitive sound detection, it is not surprising that up to …

The mammalian inner ear is a sensory organ that has specialized hair cells that detect
sound, as well as orientation and movement of the head. The'hair'bundle on the apical …

Background Mutations in the GJB2 gene cause one form of nonsyndromic recessive
deafness. Among Mediterranean Europeans, more than 80 percent of cases of …

Tight junctions in the cochlear duct are thought to compartmentalize endolymph and provide
structural support for the auditory neuroepithelium. The claudin family of genes is known to …

Deafness in humans is a common neurosensory disorder and is genetically heterogeneous.
Across diverse ethnic groups, mutations of MYO15A at the DFNB3 locus appear to be the …

Positional cloning of hereditary deafness genes is a direct approach to identify molecules
and mechanisms underlying auditory function. Here we report a locus for dominant …

Genes causing nonsyndromic autosomal recessive deafness (DFNB12) and deafness
associated with retinitis pigmentosa and vestibular dysfunction (USH1D) were previously …

The shaker-2 mouse mutation, the homolog of human DFNB3, causes deafness and circling
behavior. A bacterial artificial chromosome (BAC) transgene from the shaker-2 critical region …

DFNB3, a locus for nonsyndromic sensorineural recessive deafness, maps to a 3-
centimorgan interval on human chromosome 17p11. 2, a region that shows conserved …

The molecular basis for autosomal dominant progressive nonsyndromic hearing loss in an
Israeli Jewish family, Family H, has been determined. Linkage analysis placed this deafness …