The β‐tubulins are microtubule components encoded by a multigene family, which produces
slightly different proteins with complex expression patterns. Several widely used anticancer …

p53 Reactivation and induction of massive apoptosis (PRIMA-1) is a small-molecule
compound that reactivates mutant p53, restoring its normal tumor suppressor function …

The six major genes involved in hereditary susceptibility for pheochromocytoma
(PCC)/paraganglioma (PGL)(RET, VHL, NF1, SDHB, SDHC, and SDHD) have been recently …

In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a
candidate gene approach. We studied tag-and putative functional SNPs in genes involved in …

Context: The presence of familial history in pheochromocytoma/paraganglioma patients,
including syndromic antecedents, leads in the majority of cases to a positive genetic testing …

Therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) are
limited due to lack of effective treatments. Thus, there is a need to thoroughly characterize …

Undifferentiated and dedifferentiated endometrial carcinomas are rare and highly
aggressive subtypes of uterine cancer, not well characterized at a molecular level. To …

Background Peripheral neuropathy is the dose limiting toxicity of paclitaxel, a
chemotherapeutic drug widely used to treat solid tumours. This toxicity exhibits great inter …

Purpose: Peripheral neuropathy is the dose-limiting toxicity of paclitaxel, a
chemotherapeutic drug widely used to treat several solid tumors such as breast, lung, and …

Background: Hereditary susceptibility to familial paraganglioma syndromes is mainly due to
mutations in one of six genes, including three of the four genes encoding the subunits of the …