There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental …

Background The long time from exposure to potentially harmful chemicals until breast
cancer occurrence poses challenges for designing etiologic studies and for implementing …

Germline mutations in the tumor suppressor gene BRCA1 confer an estimated lifetime risk of
56–80% for breast cancer and 15–60% for ovarian cancer. Since the mid 1990s when …

A small proportion of breast cancer, in particular those cases arising at a young age, is due
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A …

Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …

Background Data concerning the efficacy of bilateral prophylactic oophorectomy for
reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are …

Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …

Purpose Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …

We performed a second-generation genome-wide association study of 4,533 individuals
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …