[HTML][HTML] Cancer health disparities in racial/ethnic minorities in the United States
VA Zavala, PM Bracci, JM Carethers… - British journal of …, 2021 - nature.com
There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental …
that result from the interplay between structural, socioeconomic, socio-environmental …
[HTML][HTML] Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research
Background The long time from exposure to potentially harmful chemicals until breast
cancer occurrence poses challenges for designing etiologic studies and for implementing …
cancer occurrence poses challenges for designing etiologic studies and for implementing …
A guide for functional analysis of BRCA1 variants of uncertain significance
GA Millot, MA Carvalho, SM Caputo… - Human …, 2012 - Wiley Online Library
Germline mutations in the tumor suppressor gene BRCA1 confer an estimated lifetime risk of
56–80% for breast cancer and 15–60% for ovarian cancer. Since the mid 1990s when …
56–80% for breast cancer and 15–60% for ovarian cancer. Since the mid 1990s when …
Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13
R Wooster, SL Neuhausen, J Mangion, Y Quirk, D Ford… - Science, 1994 - science.org
A small proportion of breast cancer, in particular those cases arising at a young age, is due
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A …
to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A …
Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …
[HTML][HTML] Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations
TR Rebbeck, HT Lynch, SL Neuhausen… - … England Journal of …, 2002 - Mass Medical Soc
Background Data concerning the efficacy of bilateral prophylactic oophorectomy for
reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are …
reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are …
[HTML][HTML] Breast-Cancer Risk in Families with Mutations in PALB2
AC Antoniou, S Casadei, T Heikkinen… - … England Journal of …, 2014 - Mass Medical Soc
Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …
[PDF][PDF] Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
TR Rebbeck, T Friebel, HT Lynch… - Journal of clinical …, 2004 - seom.org
Purpose Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …
Multiple common variants for celiac disease influencing immune gene expression
We performed a second-generation genome-wide association study of 4,533 individuals
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
FR Schumacher, AA Al Olama, SI Berndt, S Benlloch… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …