Surgical treatment of congenital hyperinsulinism: results from 500 pancreatectomies in neonates and children

NS Adzick, DD De Leon, LJ States, K Lord… - Journal of pediatric …, 2019 - Elsevier
Abstract Background Congenital Hyperinsulinism (HI) causes severe hypoglycemia in
neonates and children. We reviewed our experience with pancreatectomy for the various …

Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith–Wiedemann syndrome

JM Kalish, KE Boodhansingh, TR Bhatti… - Journal of Medical …, 2016 - jmg.bmj.com
Background Congenital hyperinsulinism (HI) can have monogenic or syndromic causes.
Although HI has long been recognised to be common in children with Beckwith–Wiedemann …

Accuracy of PET/CT scan in the diagnosis of the focal form of congenital hyperinsulinism

P Laje, LJ States, H Zhuang, SA Becker… - Journal of pediatric …, 2013 - Elsevier
PURPOSE: The purpose of the study was to determine the sensitivity of the 18fluoro-
dihydroxyphenylalanine positron emission tomography/computed tomography scan (18F …

Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1

CM MacMullen, Q Zhou, KE Snider, PH Tewson… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Congenital hyperinsulinemic hypoglycemia is a group of genetic disorders of
insulin secretion most commonly associated with inactivating mutations of the β-cell ATP …

Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism

TT Huang, A Kelly, SA Becker, MS Cohen… - Archives of Disease in …, 2013 - fn.bmj.com
Introduction Hypertrophic cardiomyopathy (HCM) is a well-recognised complication in
infants of diabetic mothers and is attributed to a compensatory increase in fetal insulin …

Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism

P Laje, CA Stanley, AA Palladino, SA Becker… - Journal of pediatric …, 2012 - Elsevier
PURPOSE: To determine the outcome of patients who underwent pancreatic head resection
and Roux-en-Y pancreaticojejunostomy to the remaining normal pancreatic body and tail for …

Congenital Hyperinsulinism in Infants with Turner Syndrome: Possible Association with Monosomy X and KDM6A Haploinsufficiency

CE Gibson, KE Boodhansingh, C Li, L Conlin… - Hormone research in …, 2018 - karger.com
Background: Previous case reports have suggested a possible association of congenital
hyperinsulinism with Turner syndrome. Objective: We examined the clinical and molecular …

The surgical management of insulinomas in children

WH Peranteau, AA Palladino, TR Bhatti… - Journal of Pediatric …, 2013 - Elsevier
Purpose Insulinomas are rare pediatric tumors for which optimal localization studies and
management remain undetermined. We present our experience with surgical management …

Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to ABCC8 and GCK mosaic mutations

KE Boodhansingh, Z Yang, C Li, P Chen… - European journal of …, 2022 - academic.oup.com
Objective Congenital hyperinsulinism (HI) is the most common cause of persistent
hypoglycemia in children. In addition to typical focal or diffuse HI, some cases with diazoxide …

18F-6-Fluoro-l-Dopa PET/CT imaging of congenital hyperinsulinism

JC Davis, SM Hamel, SA Becker… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Congenital hyperinsulinism is characterized by persistent hypoglycemia due to
inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia. The …