Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolic cofactor in eukaryotic cells
that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD+ in …

Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

Mutations in the mitochondrial DNA (mtDNA) can cause a variety of human diseases. In
most cases, such mutations are heteroplasmic (ie mutated and wild-type mtDNA coexist) …

Mitochondrial DNA (mtDNA) deletions are a common cause of mitochondrial disorders and
have been found to accumulate during normal aging. Despite the fact that hundreds of …

Members of the peroxisome proliferator-activated receptor γ coactivator (PGC) family are
potent inducers of mitochondrial biogenesis. We have tested the potential effect of increased …

Aging is the major known risk factor for the onset of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease (PD). Mitochondria play a central role in …

The phenotypic spectrum among girls with heterozygous mutations in the X-linked
intellectual disability (XLID) gene CASK (calcium/calmodulin-dependent serine protein …

Abstract Mitochondrial DNA (mtDNA) 3243A> G tRNALeu (UUR) heteroplasmic mutation (m.
3243A> G) exhibits clinically heterogeneous phenotypes. While the high mtDNA …

Deletion and truncation mutations in the X-linked gene CASK are associated with severe
intellectual disability (ID), microcephaly and pontine and cerebellar hypoplasia in girls …