Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …

Familial clustering studies indicate that breast cancer risk has a substantial genetic
component,,. To identify new breast cancer risk variants, we genotyped approximately …

Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a
higher proportion occurring in younger women and women of African ancestry. The etiology …

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility
loci, but these explain only a small fraction of the familial risk of the disease. Five of these …

We carried out a genome-wide association study of breast cancer predisposition with
replication and refinement studies involving 6,145 cases and 33,016 controls and identified …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy …