Molecular Dynamics (MD) Simulations is increasingly used as a powerful tool to study
protein structure-related questions. Starting from the early simulation study on the …

A critical and difficult part of studying cancer with DNA microarrays is data interpretation.
Besides the need for data analysis algorithms, integration of additional information about …

MicroRNAs (miRNAs) are small, endogenously expressed RNAs that regulate mRNAs post-
transcriptionally. The class of miRNA genes, like other gene classes, should experience …

Recent findings have established a connection between DNA methylation and
transcriptionally inactive chromatin characterized by deacetylated histones. Because the …

We have analyzed a systematic flaw in the current system of gene identification: the oligo
(dT) primer widely used for cDNA synthesis generates a high frequency of truncated cDNAs …

In this study, we compared the genomic integration efficiencies and transposition site
preferences of Sleeping Beauty (SB or SB11), Tol2, and piggyBac (PB) transposon systems …

The biological effect of radiofrequency (RF) fields remains controversial. We address this
issue by examining whether RF fields can cause changes in gene expression. We used the …

Serial analysis of gene expression (SAGE) is a method for identifying and quantifying
transcripts from eukaryotic genomes. Since its invention, SAGE has been widely applied to …

Pathogenic mutation in BRCA1 gene is one of the most penetrant genetic predispositions
towards cancer. Identification of the mutation provides important aspect in prevention and …

Background Transcripts expressed in eukaryotes are classified as poly A+ transcripts or poly
A-transcripts based on the presence or absence of the 3′ poly A tail. Most transcripts …