User profiles for "author:Sakae Tanaka"
"Sakae Tanaka"The University of Tokyo Verified email at hu-tokyo.ac.jp Cited by 33979 |
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL–RANK signaling system
S Tanaka, K Nakamura, N Takahasi… - Immunological …, 2005 - Wiley Online Library
Osteoclasts are primary cells for physiological and pathological bone resorption, and
receptor activator of nuclear factor‐κB ligand (RANKL) is critically involved in the …
receptor activator of nuclear factor‐κB ligand (RANKL) is critically involved in the …
[HTML][HTML] Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
T Saito, S Tanaka - Arthritis research & therapy, 2017 - Springer
Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since
the establishment of murine surgical knee OA models in 2005, many of the key molecules …
the establishment of murine surgical knee OA models in 2005, many of the key molecules …
Pathomechanism of intervertebral disc degeneration
T Oichi, Y Taniguchi, Y Oshima, S Tanaka, T Saito - JOR spine, 2020 - Wiley Online Library
Intervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a
leading cause of disability worldwide. Although substantial progress has been made in …
leading cause of disability worldwide. Although substantial progress has been made in …
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
K Sato, A Suematsu, K Okamoto… - The Journal of …, 2006 - rupress.org
In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the
activation of T cells results in bone destruction mediated by osteoclasts, but how T cells …
activation of T cells results in bone destruction mediated by osteoclasts, but how T cells …
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
N Komatsu, K Okamoto, S Sawa, T Nakashima… - Nature medicine, 2014 - nature.com
Autoimmune diseases often result from an imbalance between regulatory T (Treg) cells and
interleukin-17 (IL-17)-producing T helper (TH17) cells; the origin of the latter cells remains …
interleukin-17 (IL-17)-producing T helper (TH17) cells; the origin of the latter cells remains …
[HTML][HTML] Force sensing by mechanical extension of the Src family kinase substrate p130Cas
Y Sawada, M Tamada, BJ Dubin-Thaler… - Cell, 2006 - cell.com
How physical force is sensed by cells and transduced into cellular signaling pathways is
poorly understood. Previously, we showed that tyrosine phosphorylation of p130Cas (Cas) …
poorly understood. Previously, we showed that tyrosine phosphorylation of p130Cas (Cas) …
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
T Tamura, N Udagawa, N Takahashi… - Proceedings of the …, 1993 - National Acad Sciences
It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum
of healthy individuals and its level is increased in patients with multiple myeloma and human …
of healthy individuals and its level is increased in patients with multiple myeloma and human …
Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice
A Naito, S Azuma, S Tanaka, T Miyazaki… - Genes to …, 1999 - Wiley Online Library
Background TRAF6, a member of the tumour necrosis factor receptor‐associated factor
family, was first identified as a transducer of CD40 and interleukin‐1 receptor (IL‐1R) signals …
family, was first identified as a transducer of CD40 and interleukin‐1 receptor (IL‐1R) signals …
Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
H Takayanagi, H Iizuka, T Juji… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To clarify the mechanism by which osteoclasts are formed in culture of rheumatoid
synoviocytes by exploring the involvement of receptor activator of nuclear factor κB ligand …
synoviocytes by exploring the involvement of receptor activator of nuclear factor κB ligand …
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.
S Tanaka, N Takahashi, N Udagawa… - The Journal of …, 1993 - Am Soc Clin Investig
The mechanism of action of macrophage colony-stimulating factor (M-CSF) in osteoclast
development was examined in a co-culture system of mouse osteoblastic cells and spleen …
development was examined in a co-culture system of mouse osteoblastic cells and spleen …