User profiles for "author:S Leach"

Steven Leach

Professor of Molecular and Systems Biology, Dartmouth College
Verified email at dartmouth.edu
Cited by 32619

Time lines of infection and disease in human influenza: a review of volunteer challenge studies

…, M Lemaitre, S Cauchemez, S Leach… - American journal of …, 2008 - academic.oup.com
The dynamics of viral shedding and symptoms following influenza virus infection are key
factors when considering epidemic control measures. The authors reviewed published …

The antigenic structure of proteins: a reappraisal

DC Benjamin, JA Berzofsky, IJ East… - Annual review of …, 1984 - annualreviews.org
Proteins are one of the most abundant and diverse classes of antigens to which the immune
system can respond. These include trarisplantation antigens, anti gens of infectious and …

Pancreatic cancer

TP Yeo, RH Hruban, SD Leach, RE Wilentz… - Current problems in …, 2002 - Elsevier
I n the United States there are 28,000 to 30,300 newly diagnosed cases of pancreatic cancer
and approximately an equal number of deaths per year from pancreatic cancer. 1, 2 Ductal …

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

S Jones, X Zhang, DW Parsons, JCH Lin, RJ Leary… - science, 2008 - science.org
There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end …

The genome sequence of the SARS-associated coronavirus

MA Marra, SJM Jones, CR Astell, RA Holt… - Science, 2003 - science.org
We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–
associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this …

A draft map of the human proteome

MS Kim, SM Pinto, D Getnet, RS Nirujogi, SS Manda… - Nature, 2014 - nature.com
The availability of human genome sequence has transformed biomedical research over the
past decade. However, an equivalent map for the human proteome with direct …

Planck 2013 results. XXII. Constraints on inflation

…, RJ Laureijs, CR Lawrence, S Leach… - Astronomy & …, 2014 - aanda.org
We analyse the implications of the Planck data for cosmic inflation. The Planck nominal
mission temperature anisotropy measurements, combined with the WMAP large-angle …

[PDF][PDF] Organoid models of human and mouse ductal pancreatic cancer

SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle… - Cell, 2015 - cell.com
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited
response to treatment. Tractable methods to identify and interrogate pathways involved in …

Early intensive care unit mobility therapy in the treatment of acute respiratory failure

…, L Penley, A Howard, L Dixon, S Leach… - Critical care …, 2008 - journals.lww.com
Objective: Immobilization and subsequent weakness are consequences of critical illness.
Despite the theoretical advantages of physical therapy to address this problem, it has not …

[HTML][HTML] EMT and dissemination precede pancreatic tumor formation

AD Rhim, ET Mirek, NM Aiello, A Maitra, JM Bailey… - Cell, 2012 - cell.com
Metastasis is the leading cause of cancer-associated death but has been difficult to study
because it involves a series of rare, stochastic events. To capture these events, we …