[HTML][HTML] Breast cancer prognostic classification in the molecular era: the role of histological grade

…, DJ Dabbs, T Decker, V Eusebi, SB Fox, S Ichihara… - Breast cancer …, 2010 - Springer
Breast cancer is a heterogeneous disease with varied morphological appearances,
molecular features, behavior, and response to therapy. Current routine clinical management …

[HTML][HTML] Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

…, FL Baehner, T Decker, V Eusebi, SB Fox, S Ichihara… - Modern pathology, 2011 - Elsevier
Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct
morphological features and clinical behaviors. Although morphology is often associated with …

Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management

…, G Ichihara, MK Uddin, M Kurasaki, S Ichihara - Environmental …, 2021 - Elsevier
Arsenic is a well-recognized environmental contaminant that occurs naturally through
geogenic processes in the aquifer. More than 200 million people around the world are …

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

…, W Huang, YJ Hung, MY Hwang, CM Hwu, S Ichihara… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …

[HTML][HTML] Prediction of the risk of myocardial infarction from polymorphisms in candidate genes

Y Yamada, H Izawa, S Ichihara, F Takatsu… - … England Journal of …, 2002 - Mass Medical Soc
Background Although epidemiologic studies have suggested that several genetic variants
increase the risk of myocardial infarction, large-scale association studies that examine many …

Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II–induced hypertension

S Ichihara, T Senbonmatsu, E Price Jr, T Ichiki… - Circulation, 2001 - Am Heart Assoc
Background The roles of angiotensin II (Ang II) in the regulation of heart function under
normal and pathological conditions have been well documented. Although 2 types of Ang II …

Presence of Epidermal Growth Factor Receptor Gene T790M Mutation as a Minor Clone in Non–Small Cell Lung Cancer

M Inukai, S Toyooka, S Ito, H Asano, S Ichihara, J Soh… - Cancer research, 2006 - AACR
The threonine-to-methionine substitution at amino acid position 790 (T790M) of the
epidermal growth factor receptor (EGFR) gene has been reported in progressing lesions …

Phyllodes tumours of the breast: a consensus review

…, V Eusebi, G Farshid, SB Fox, S Ichihara… - …, 2016 - Wiley Online Library
Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial
lesions. Accurate and reproducible grading of these tumours has long been challenging …

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

…, W Huang, LLN Husemoen, JY Hwang, S Ichihara… - Nature …, 2015 - nature.com
We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Identification of type 2 diabetes loci in 433,540 East Asian individuals

…, W Huang, YJ Hung, MY Hwang, CM Hwu, S Ichihara… - Nature, 2020 - nature.com
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …