Musculoskeletal disorders (MSDs) are the leading cause of work disability, sickness
absence from work,'presenteeism'and loss of productivity across all the European Union …

Background and Purpose—Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

Capsaicin acts specifically on a subset of primary afferent sensory neurons to open cation-
selective ion channels, probably by interacting directly with a membrane receptor-ion …

Mammals detect temperature with specialized neurons in the peripheral nervous system.
Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class …

Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is
known about their etiology and pathogenesis 1, 2, 3. We previously mapped a gene that …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

A distinct subset of sensory neurons are thought to directly sense changes in thermal energy
through their termini in the skin. Very little is known about the molecules that mediate …

Familial juvenile polyposis is an autosomal dominant disease characterized by a
predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a …

Mechanical and thermal cues stimulate a specialized group of sensory neurons that
terminate in the skin. Three members of the transient receptor potential (TRP) family of …

1. In current‐clamp recordings, 1 microM prostaglandin E2 (PGE2) increased the excitability
of neonatal rat dorsal root ganglion neurones. The current threshold for firing was reduced …