Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of
the atopic diathesis. Recent evidence supports the concept that AD can also recognize other …

About 15 years have gone by since Strachan first proposed the idea that infections and
unhygienic contact might confer protection against the development of allergic illnesses. The …

The prevalence of allergic diseases has significantly increased in industrialized countries.
Allergen-specific immunotherapy (AIT) remains as the only curative treatment. The …

Background In early life, the innate immune system can recognize both viable and nonviable
parts of microorganisms. Immune activation may direct the immune response, thus …

BACKGROUND: There is increasing evidence that environmental exposures determining
childhood illnesses operate early in life. Prenatal exposure to a farming environment …

Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

Background Dietary changes are suggested to play a role in the increasing prevalence of
allergic diseases and asthma. Short‐chain fatty acids (SCFA s) are metabolites present in …

Background Dietary interventions as a means for atopy prevention attract great interest.
Some studies in rural environments claimed an inverse association between consumption of …

BACKGROUND: In recent years, studies have shown a protective effect of being raised in a
farm environment on the development of hay fever and atopic sensitization. Inconsistent …

Toll-like receptors (TLRs) are involved in mediating cell activation on stimulation with
microbial constituents. We investigated the role for TLRs in synovial fibroblast (SF) activation …