User profiles for "author:Pierre Gressens"

pierre gressens

Verified email at inserm.fr
Cited by 33767

Microglia states and nomenclature: A field at its crossroads

RC Paolicelli, A Sierra, B Stevens, ME Tremblay… - Neuron, 2022 - cell.com
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

The role of inflammation in perinatal brain injury

H Hagberg, C Mallard, DM Ferriero… - Nature Reviews …, 2015 - nature.com
Inflammation is increasingly recognized as being a critical contributor to both normal
development and injury outcome in the immature brain. The focus of this Review is to …

Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults

H Hagberg, P Gressens, C Mallard - Annals of neurology, 2012 - Wiley Online Library
Inflammation is increasingly recognized as being of both physiological and pathological
importance in the immature brain. The rationale of this review is to present an update on this …

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

B Oosthuyse, L Moons, E Storkebaum, H Beck… - Nature …, 2001 - nature.com
Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the
hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here …

Role of tissue factor in embryonic blood vessel development

P Carmeliet, N Mackman, L Moons, T Luther… - Nature, 1996 - nature.com
TISSUE factor, a member of the cytokine-receptor superfamily and high-affinity receptor and
cofactor for plasma factor Vll/VIIa (ref. 1), is the primary cellular initiator of blood coagulation …

[HTML][HTML] Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

V Chhor, T Le Charpentier, S Lebon, MV Oré… - Brain, behavior, and …, 2013 - Elsevier
Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair,
regeneration, and immunosuppression due to their ability to acquire diverse activation …

[PDF][PDF] Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses

L Meertens, A Labeau, O Dejarnac, S Cipriani… - Cell reports, 2017 - cell.com
ZIKA virus (ZIKV) is an emerging pathogen responsible for neurological disorders and
congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains …

Systemic inflammation disrupts the developmental program of white matter

G Favrais, Y Van De Looij, B Fleiss… - Annals of …, 2011 - Wiley Online Library
Objective: Perinatal inflammation is a major risk factor for neurological deficits in preterm
infants. Several experimental studies have shown that systemic inflammation can alter the …

The yin and yang of microglia

M Czeh, P Gressens, AM Kaindl - Developmental neuroscience, 2011 - karger.com
Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a
pivotal role in both physiological and pathological conditions such as the restoration of CNS …

Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?

B Fleiss, P Gressens - The Lancet Neurology, 2012 - thelancet.com
Cerebral palsy is caused by injury or developmental disturbances to the immature brain and
leads to substantial motor, cognitive, and learning deficits. In addition to developmental …