User profiles for "author:Patrizia Sarogni"
Patrizia SarogniIsituto Italiano di Tecnologia Verified email at iit.it Cited by 346 |
Cornelia de Lange syndrome: from molecular diagnosis to therapeutic approach
Cornelia de Lange syndrome (CdLS) is a severe genetic disorder characterised by
multisystemic malformations. CdLS is due to pathogenetic variants in NIPBL, SMC1A …
multisystemic malformations. CdLS is due to pathogenetic variants in NIPBL, SMC1A …
Tumor grafted–chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation
AK Mapanao, PP Che, P Sarogni, P Sminia… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Advancements in cancer management and treatment are associated with
strong preclinical research data, in which reliable cancer models are demanded. Indeed …
strong preclinical research data, in which reliable cancer models are demanded. Indeed …
Pathogenic variants in EP300 and ANKRD11 in patients with phenotypes overlapping Cornelia de Lange syndrome
Abstract Cornelia de Lange syndrome (CdLS), Rubinstein–Taybi syndrome (RSTS), and
KBG syndrome are three distinct developmental human disorders. Variants in seven genes …
KBG syndrome are three distinct developmental human disorders. Variants in seven genes …
[HTML][HTML] Pro-apoptotic and size-reducing effects of protein corona-modulating nano-architectures enclosing platinum prodrug in in vivo oral carcinoma
The selective and localized delivery of active agents to neoplasms is crucial to enhance the
chemotherapeutic efficacy while reducing the associated side effects. The encapsulation of …
chemotherapeutic efficacy while reducing the associated side effects. The encapsulation of …
[PDF][PDF] Chorioallantoic membrane tumor models highlight the effects of cisplatin compounds in oral carcinoma treatment
Summary The European Society for Medical Oncology (ESMO) suggests the use of
chemotherapy as neoadjuvant, adjuvant, and concomitant to surgery and radiotherapy for …
chemotherapy as neoadjuvant, adjuvant, and concomitant to surgery and radiotherapy for …
[HTML][HTML] Hybrid nano-architectures loaded with metal complexes for the co-chemotherapy of head and neck carcinomas
Head and neck squamous cell carcinomas (HNSCCs) are a complex group of malignancies
that affect different body sites pertaining to the oral cavity, pharynx and larynx. Current …
that affect different body sites pertaining to the oral cavity, pharynx and larynx. Current …
[HTML][HTML] Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development
Background Cancer cells are characterized by chromosomal instability (CIN) and it is
thought that errors in pathways involved in faithful chromosome segregation play a pivotal …
thought that errors in pathways involved in faithful chromosome segregation play a pivotal …
Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo
D Cukrov, TAC Newman, M Leask… - Human molecular …, 2018 - academic.oup.com
Abstract Cornelia de Lange syndrome (CdLS) is a rare disease characterized by cognitive
impairment, multisystemic alterations and premature aging. Furthermore, CdLS cells display …
impairment, multisystemic alterations and premature aging. Furthermore, CdLS cells display …
[HTML][HTML] Targeting heparan sulfate proteoglycans as a novel therapeutic strategy for mucopolysaccharidoses
V De Pasquale, P Sarogni, V Pistorio, G Cerulo… - … Therapy Methods & …, 2018 - cell.com
Mucopolysaccharidoses (MPSs) are inherited metabolic diseases caused by the deficiency
of lysosomal enzymes needed to catabolize glycosaminoglycans (GAGs). Four therapeutic …
of lysosomal enzymes needed to catabolize glycosaminoglycans (GAGs). Four therapeutic …
[HTML][HTML] EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis …
Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the
deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate …
deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate …