User profiles for "author:Patrizia Sarogni"

Patrizia Sarogni

Isituto Italiano di Tecnologia
Verified email at iit.it
Cited by 346

Cornelia de Lange syndrome: from molecular diagnosis to therapeutic approach

P Sarogni, MM Pallotta, A Musio - Journal of medical genetics, 2020 - jmg.bmj.com
Cornelia de Lange syndrome (CdLS) is a severe genetic disorder characterised by
multisystemic malformations. CdLS is due to pathogenetic variants in NIPBL, SMC1A …

Tumor grafted–chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation

AK Mapanao, PP Che, P Sarogni, P Sminia… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Advancements in cancer management and treatment are associated with
strong preclinical research data, in which reliable cancer models are demanded. Indeed …

Pathogenic variants in EP300 and ANKRD11 in patients with phenotypes overlapping Cornelia de Lange syndrome

F Cucco, P Sarogni, S Rossato, M Alpa… - American Journal of …, 2020 - Wiley Online Library
Abstract Cornelia de Lange syndrome (CdLS), Rubinstein–Taybi syndrome (RSTS), and
KBG syndrome are three distinct developmental human disorders. Variants in seven genes …

[HTML][HTML] Pro-apoptotic and size-reducing effects of protein corona-modulating nano-architectures enclosing platinum prodrug in in vivo oral carcinoma

AK Mapanao, P Sarogni, M Santi, M Menicagli… - Biomaterials …, 2022 - pubs.rsc.org
The selective and localized delivery of active agents to neoplasms is crucial to enhance the
chemotherapeutic efficacy while reducing the associated side effects. The encapsulation of …

[PDF][PDF] Chorioallantoic membrane tumor models highlight the effects of cisplatin compounds in oral carcinoma treatment

P Sarogni, AK Mapanao, A Gonnelli, ML Ermini… - IScience, 2022 - cell.com
Summary The European Society for Medical Oncology (ESMO) suggests the use of
chemotherapy as neoadjuvant, adjuvant, and concomitant to surgery and radiotherapy for …

[HTML][HTML] Hybrid nano-architectures loaded with metal complexes for the co-chemotherapy of head and neck carcinomas

M Santi, V Frusca, ML Ermini, AK Mapanao… - Journal of Materials …, 2023 - pubs.rsc.org
Head and neck squamous cell carcinomas (HNSCCs) are a complex group of malignancies
that affect different body sites pertaining to the oral cavity, pharynx and larynx. Current …

[HTML][HTML] Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

P Sarogni, O Palumbo, A Servadio, S Astigiano… - Journal of Experimental …, 2019 - Springer
Background Cancer cells are characterized by chromosomal instability (CIN) and it is
thought that errors in pathways involved in faithful chromosome segregation play a pivotal …

Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo

D Cukrov, TAC Newman, M Leask… - Human molecular …, 2018 - academic.oup.com
Abstract Cornelia de Lange syndrome (CdLS) is a rare disease characterized by cognitive
impairment, multisystemic alterations and premature aging. Furthermore, CdLS cells display …

[HTML][HTML] Targeting heparan sulfate proteoglycans as a novel therapeutic strategy for mucopolysaccharidoses

V De Pasquale, P Sarogni, V Pistorio, G Cerulo… - … Therapy Methods & …, 2018 - cell.com
Mucopolysaccharidoses (MPSs) are inherited metabolic diseases caused by the deficiency
of lysosomal enzymes needed to catabolize glycosaminoglycans (GAGs). Four therapeutic …

[HTML][HTML] EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis …

V De Pasquale, A Pezone, P Sarogni… - Cell death & …, 2018 - nature.com
Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the
deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate …