[HTML][HTML] Breast-Cancer Risk in Families with Mutations in PALB2

AC Antoniou, S Casadei, T Heikkinen… - … England Journal of …, 2014 - Mass Medical Soc
Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …

Incidental carcinomas in prophylactic specimens in BRCA1 and BRCA2 germ-line mutation carriers, with emphasis on fallopian tube lesions: report of 6 cases and …

ML Carcangiu, B Peissel, B Pasini… - The American journal …, 2006 - journals.lww.com
The identification of germ-line mutations in 2 genes (BRCA1 and BRCA2) responsible for
the majority of hereditary ovarian cancers has led an increasing number of women carriers …

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 …

N Mavaddat, D Barrowdale, IL Andrulis… - … Biomarkers & Prevention, 2012 - AACR
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Prediction of breast cancer risk based on profiling with common genetic variants

N Mavaddat, PDP Pharoah… - Journal of the …, 2015 - academic.oup.com
Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …

[HTML][HTML] Oral contraceptives and the risk of hereditary ovarian cancer

SA Narod, H Risch, R Moslehi, A Dørum… - … England Journal of …, 1998 - Mass Medical Soc
Background Women with mutations in either the BRCA1 or the BRCA2 gene have a high
lifetime risk of ovarian cancer. Oral contraceptives protect against ovarian cancer in general …

Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

SR Lakhani, JS Reis-Filho, L Fulford… - Clinical cancer …, 2005 - AACR
Purpose: To investigate the proportion of breast cancers arising in patients with germ line
BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for …

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

JRB Perry, F Day, CE Elks, P Sulem, DJ Thompson… - Nature, 2014 - nature.com
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

[HTML][HTML] Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives

S Gori, M Barberis, MA Bella, F Buttitta… - Critical Reviews in …, 2019 - Elsevier
The current availability of new Poly (ADP-ribose) Polymerase (PARP)-inhibitors for the
treatment of ovarian cancer patients independently of the presence of a BRCA pathogenic …

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies

XR Yang, J Chang-Claude, EL Goode… - Journal of the …, 2011 - academic.oup.com
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

M Garcia-Closas, FJ Couch, S Lindstrom… - Nature …, 2013 - nature.com
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a
higher proportion occurring in younger women and women of African ancestry. The etiology …