Joining of the BCR and ABL genes is an essential feature of the group of human leukemias
characterized by the Philadelphia chromosome and there is recent evidence that the human …

In PHA-cultured lymphocytes, about 8% of metaphases from 32 women were aneuploid
compared to 4% of metaphases from 35 men. A significant part of this aneuploidy was …

One and sometimes both X chromosomes in cultured lymphocytes of women donors
showed division of the centromere when the centromeres of other chromosomes were …

Abstract The Philadelphia chromosome (Ph′) is found in the blood cells of about 90% of
patients with chronic myeloid leukaemia (CML) and usually results from the reciprocal …

Five related phenotypic females, representing three different sibships in the same family,
were found to have pure gonadal dysgenesis, which was confirmed by the finding of streak …

Apparent acentric fragments which replaced a C-group chromosome in cultured blood
lymphocytes from a woman patient were shown by autoradiography, G-banding and C …

One hundred cases of retinoblastoma were diagnosed in New Zealand-born children
between 1948 and 1977 inclusive. Five patients had an affected parent, and of the …

In order to define the functional defect in marrow cells in B12 and folate deficiency, ten
patients were investigated. Chromosome studies showed alterations similar to those …

The somatic chromosomes of patients with chronic lymphocytic leukaemia have hithertonot
been exten-sively studied, and there are no published accounts of any consistent …

A 16‐year‐old male with hypospadias and gynaecomastia had a rudimentary uterus with a
right Fallopian tube and ovary; the left gonad was a functioning testis. Cytogenetic studies …