User profiles for "author:Nicolas Coquelle"
Nicolas CoquelleInstitut de Biologie Structurale Verified email at ibs.fr Cited by 3100 |
The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril
E Tayeb-Fligelman, O Tabachnikov, A Moshe… - Science, 2017 - science.org
Amyloids are ordered protein aggregates, found in all kingdoms of life, and are involved in
aggregation diseases as well as in physiological activities. In microbes, functional amyloids …
aggregation diseases as well as in physiological activities. In microbes, functional amyloids …
Mechanism and dynamics of fatty acid photodecarboxylase
INTRODUCTION Photoenzymes are rare biocatalysts driven by absorption of a photon at
each catalytic cycle; they inspire development of artificial photoenzymes with valuable …
each catalytic cycle; they inspire development of artificial photoenzymes with valuable …
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor
B Brus, U Kosak, S Turk, A Pislar… - Journal of medicinal …, 2014 - ACS Publications
Butyrylcholinesterase (BChE) is regarded as a promising drug target as its levels and activity
significantly increase in the late stages of Alzheimer's disease. To discover novel BChE …
significantly increase in the late stages of Alzheimer's disease. To discover novel BChE …
Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography
Chromophores absorb light in photosensitive proteins and thereby initiate fundamental
biological processes such as photosynthesis, vision and biofluorescence. An important goal …
biological processes such as photosynthesis, vision and biofluorescence. An important goal …
Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays
MS Lee, R Green, SM Marsillac, N Coquelle… - Cancer research, 2010 - AACR
Genetic screening of the breast and ovarian cancer susceptibility gene BRCA1 has
uncovered a large number of variants of uncertain clinical significance. Here, we use …
uncovered a large number of variants of uncertain clinical significance. Here, we use …
[HTML][HTML] Raster-scanning serial protein crystallography using micro-and nano-focused synchrotron beams
High-resolution structural information was obtained from lysozyme microcrystals (20 µm in
the largest dimension) using raster-scanning serial protein crystallography on micro-and …
the largest dimension) using raster-scanning serial protein crystallography on micro-and …
An ER‐peroxisome tether exerts peroxisome population control in yeast
B Knoblach, X Sun, N Coquelle, A Fagarasanu… - The EMBO …, 2013 - embopress.org
Eukaryotic cells compartmentalize biochemical reactions into membrane‐enclosed
organelles that must be faithfully propagated from one cell generation to the next. Transport …
organelles that must be faithfully propagated from one cell generation to the next. Transport …
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
U Kosak, B Brus, D Knez, S Zakelj… - Journal of medicinal …, 2018 - ACS Publications
The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …
[HTML][HTML] Development of an in-vivo active reversible butyrylcholinesterase inhibitor
U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj… - Scientific reports, 2016 - nature.com
Alzheimer's disease (AD) is characterized by severe basal forebrain cholinergic deficit,
which results in progressive and chronic deterioration of memory and cognitive functions …
which results in progressive and chronic deterioration of memory and cognitive functions …
De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure
JP Colletier, MR Sawaya, M Gingery, JA Rodriguez… - Nature, 2016 - nature.com
BinAB is a naturally occurring paracrystalline larvicide distributed worldwide to combat the
devastating diseases borne by mosquitoes. These crystals are composed of homologous …
devastating diseases borne by mosquitoes. These crystals are composed of homologous …