User profiles for "author:Nicolas Coquelle"

Nicolas Coquelle

Institut de Biologie Structurale
Verified email at ibs.fr
Cited by 3100

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

E Tayeb-Fligelman, O Tabachnikov, A Moshe… - Science, 2017 - science.org
Amyloids are ordered protein aggregates, found in all kingdoms of life, and are involved in
aggregation diseases as well as in physiological activities. In microbes, functional amyloids …

Mechanism and dynamics of fatty acid photodecarboxylase

D Sorigué, K Hadjidemetriou, S Blangy, G Gotthard… - Science, 2021 - science.org
INTRODUCTION Photoenzymes are rare biocatalysts driven by absorption of a photon at
each catalytic cycle; they inspire development of artificial photoenzymes with valuable …

Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor

B Brus, U Kosak, S Turk, A Pislar… - Journal of medicinal …, 2014 - ACS Publications
Butyrylcholinesterase (BChE) is regarded as a promising drug target as its levels and activity
significantly increase in the late stages of Alzheimer's disease. To discover novel BChE …

Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography

N Coquelle, M Sliwa, J Woodhouse, G Schirò… - Nature Chemistry, 2018 - nature.com
Chromophores absorb light in photosensitive proteins and thereby initiate fundamental
biological processes such as photosynthesis, vision and biofluorescence. An important goal …

Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays

MS Lee, R Green, SM Marsillac, N Coquelle… - Cancer research, 2010 - AACR
Genetic screening of the breast and ovarian cancer susceptibility gene BRCA1 has
uncovered a large number of variants of uncertain clinical significance. Here, we use …

[HTML][HTML] Raster-scanning serial protein crystallography using micro-and nano-focused synchrotron beams

N Coquelle, AS Brewster, U Kapp, A Shilova… - … Section D: Biological …, 2015 - scripts.iucr.org
High-resolution structural information was obtained from lysozyme microcrystals (20 µm in
the largest dimension) using raster-scanning serial protein crystallography on micro-and …

An ER‐peroxisome tether exerts peroxisome population control in yeast

B Knoblach, X Sun, N Coquelle, A Fagarasanu… - The EMBO …, 2013 - embopress.org
Eukaryotic cells compartmentalize biochemical reactions into membrane‐enclosed
organelles that must be faithfully propagated from one cell generation to the next. Transport …

The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity

U Kosak, B Brus, D Knez, S Zakelj… - Journal of medicinal …, 2018 - ACS Publications
The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …

[HTML][HTML] Development of an in-vivo active reversible butyrylcholinesterase inhibitor

U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj… - Scientific reports, 2016 - nature.com
Alzheimer's disease (AD) is characterized by severe basal forebrain cholinergic deficit,
which results in progressive and chronic deterioration of memory and cognitive functions …

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure

JP Colletier, MR Sawaya, M Gingery, JA Rodriguez… - Nature, 2016 - nature.com
BinAB is a naturally occurring paracrystalline larvicide distributed worldwide to combat the
devastating diseases borne by mosquitoes. These crystals are composed of homologous …