Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

As a preliminary step to beginning to assess the usefulness of clinical vignettes to measure
ethical sensitivity in undergraduate medical students, five clinical vignettes with seven to …

In the advanced stages of many cancers, tumor cells disseminate from the primary site and
colonize distant locations such as the skeleton. These disseminated tumor cells colonizing …

Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering
potentially curative outcomes. Despite its success, tumour cells can become resistant to RT …

Hypoxia is one of the most common phenotypes of malignant tumours. Hypoxia leads to the
increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of …

Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy - Chemical
Communications (RSC Publishing) DOI:10.1039/C2CC33913G Royal Society of Chemistry View …

Medical Education 2011: 45: 95–106 Objectives One hundred years after the Flexner report
remade medical education in North America, many countries are reviewing the purpose and …

Androgen withdrawal induces hypoxia in androgen‐sensitive tissue; this is important as in
the tumour microenvironment, hypoxia is known to drive malignant progression. Our study …

The potential role of neutrophil elastase in exacerbating pulmonary infection and tissue
damage in cystic fibrosis (CF) has led to proposals for treatment of lung disease in CF with …

Purpose: To understand the role of hypoxia in prostate tumor progression and to evaluate
the ability of the novel unidirectional hypoxia-activated prodrug OCT1002 to enhance the …