Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB

T Tanaka, N Motoi, Y Tsuchihashi, R Tazawa… - Journal of medical …, 2011 - jmg.bmj.com
Background Disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF)
signalling causes pulmonary alveolar proteinosis (PAP). Rarely, genetic defects in neonatal …

[HTML][HTML] Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis

K Ohashi, A Sato, T Takada, T Arai, T Nei… - Respiratory …, 2012 - Elsevier
BACKGROUND: Autoimmune pulmonary alveolar proteinosis (aPAP) is caused by
granulocyte/macrophage-colony stimulating factor (GM-CSF) autoantibodies in the lung …

[HTML][HTML] Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model

T Saraya, K Nakata, K Nakagaki, N Motoi, K Iihara… - Results in …, 2011 - Elsevier
Human Mycoplasma pneumoniae (MP) pneumonia is characterized by alveolar infiltration
with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri …

Identification and characterization of nucleoplasmin 3 as a histone‐binding protein in embryonic stem cells

N Motoi, K Suzuki, R Hirota, P Johnson… - Development …, 2008 - Wiley Online Library
Embryonic stem (ES) cells are thought to have unique chromatin structures responsible for
their capacity for self‐renewal and pluripotency. To examine this possibility, we sought …

[HTML][HTML] Light chain (κ/λ) ratio of GM-CSF autoantibodies is associated with disease severity in autoimmune pulmonary alveolar proteinosis

T Nei, S Urano, Y Itoh, N Kitamura, A Hashimoto… - Clinical …, 2013 - Elsevier
Previous studies demonstrated that antigranulocyte colony-stimulating factor autoantibody
(GMAb) was consistently present in patients with autoimmune pulmonary alveolar …

IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis

T Nei, S Urano, N Motoi, J Takizawa… - … of Physiology-Lung …, 2012 - journals.physiology.org
The granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody (GMAb) is
the causative agent underlying autoimmune pulmonary alveolar proteinosis (aPAP). It …

A cell-free assay to estimate the neutralizing capacity of granulocyte–macrophage colony-stimulating factor autoantibodies

S Urano, C Kaneko, T Nei, N Motoi, R Tazawa… - Journal of …, 2010 - Elsevier
The aim of the project is to develop a novel method estimating granulocyte–macrophage
colony-stimulating factor (GM-CSF) neutralizing capacity with high-throughput and good …

Spatiotemporal expression profile of no29/nucleophosmin3 in the intestine of Xenopus laevis during metamorphosis

N Motoi, T Hasebe, KT Suzuki, A Ishizuya-Oka - Cell and Tissue Research, 2011 - Springer
A Xenopus laevis homolog of nucleophosmin/nucleoplasmin3 (NPM3), no29, has been
previously identified as a thyroid hormone (TH)-response gene during TH-induced …

Memory B cell pool of autoimmune pulmonary alveolar proteinosis patients contains higher frequency of GM-CSF autoreactive B cells than healthy subjects

T Nei, S Urano, N Motoi, A Hashimoto, N Kitamura… - Immunology …, 2019 - Elsevier
The IgG-type neutralizing GM-CSF autoantibody (GMAb) is known to be the causative agent
for autoimmune pulmonary alveolar proteinosis (APAP). Previous studies report that serum …

A case of acquired pulmonary alveolar proteinosis with defective signaling through common beta chain of GM-CSF receptor

N Motoi, T Tanaka, Y Tsuchihashi… - … OF DIFFUSE LUNG …, 2010 - atsjournals.org
RATIONALE: To date, several congenital cases with defective GM-CSF receptor alpha or
beta chain signaling have been reported. Here, we report the first acquired case in which …