Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …

Low-risk myelodysplastic syndrome (MDS) with normal cytogenetics accounts for
approximately 50% of MDS patients. There are no pathognomonic markers in these cases …

The breakdown of toll-like receptor (TLR) tolerance results in tissue damage, and
hyperactivation of the TLRs and subsequent inflammatory consequences have been …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with
phenotypic and genetic heterogeneity. Approximately 10% of cases are familial, while …

Background Aberrant or impaired repair of double-strand DNA breaks is a common feature
of de novo acute myeloid leukemia and myelodysplastic syndromes. Since poly (ADP …

The phenotype of osteoblastic (OB) cells in culture is currently defined using a limited
number of markers of low sensitivity and specificity. For the clinical use of human skeletal …

Alzheimer's disease (AD) is a complex genetic disease, and variants identified through
genome-wide association studies (GWAS) explain only part of its heritability. Epistasis has …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by
the loss of upper and lower motor neurons. ALS exhibits high phenotypic variability …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by the
loss of upper and lower motor neurons resulting in paralysis and eventual death …

The CACCC-box binding protein erythroid Krüppel-like factor (EKLF/KLF1) is a master
regulator that directs the expression of many important erythroid genes. We have previously …