[HTML][HTML] Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology

AM Ramos, RPMA Crooijmans, NA Affara, AJ Amaral… - PloS one, 2009 - journals.plos.org
Background The dissection of complex traits of economic importance to the pig industry
requires the availability of a significant number of genetic markers, such as single nucleotide …

Germline mutations in the Von Hippel‐Lindau disease (VHL) gene in families from North America, Europe, and Japan

B Zbar, T Kishida, F Chen, L Schmidt… - Human …, 1996 - Wiley Online Library
Germline mutation analysis was performed in 469 VHL families from North America, Europe,
and Japan. Germline mutations were identified in 300/469 (63%) of the families tested; 137 …

Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes

AH Handyside, GL Harton, B Mariani… - Journal of medical …, 2010 - jmg.bmj.com
The use of genome wide single nucleotide polymorphism (SNP) arrays for high resolution
molecular cytogenetic analysis using a combination of quantitative and genotype analysis is …

Somatic mutations of the von Hippel—Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

K Foster, A Prowse, A van den Berg… - Human molecular …, 1994 - academic.oup.com
Loss of heterozygosity (LOH) studies have suggested that somatic mutations of a tumour
suppressor gene or genes on chromosome 3p are a critical event In the pathogenesls of non …

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL …

SC Clifford, AH Prowse, NA Affara… - Genes …, 1998 - Wiley Online Library
Inactivation of tumour suppressor gene (s)(TSGs) on 3p appears to be a critical event in the
pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity …

Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.

AH Prowse, AR Webster, FM Richards… - American journal of …, 1997 - ncbi.nlm.nih.gov
Abstract Von Hippel-Lindau (VHL) disease is a dominantly inherited disorder predisposing
to retinal and CNS hemangioblastomas, renal cell carcinoma (RCC), pheochromocytoma …

An improved pig reference genome sequence to enable pig genetics and genomics research

A Warr, N Affara, B Aken, H Beiki, DM Bickhart… - …, 2020 - academic.oup.com
Abstract Background The domestic pig (Sus scrofa) is important both as a food source and
as a biomedical model given its similarity in size, anatomy, physiology, metabolism …

Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y …

GM Brown, RA Furlong, CA Sargent… - Human Molecular …, 1998 - academic.oup.com
DFFRY (the Y-linked homologue of the DFFRX Drosophila fat-facets related X gene) maps
to proximal Yq11. 2 within the interval defining the AZFa spermatogenic phenotype. The …

Sperm-induced modification of the oviductal gene expression profile after natural insemination in mice

A Fazeli, NA Affara, M Hubank… - Biology of …, 2004 - academic.oup.com
In mammals, the physiological interaction between spermatozoa and oviductal epithelia
involves intimate and specific contact between the two cell types. Spermatozoa may …

[HTML][HTML] A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse

J Cocquet, PJI Ellis, SK Mahadevaiah, NA Affara… - 2012 - journals.plos.org
Intragenomic conflicts arise when a genetic element favours its own transmission to the
detriment of others. Conflicts over sex chromosome transmission are expected to have …