Background Mutations in the gene encoding mitochondrial DNA polymerase γ (POLG), the
enzyme that synthesises mitochondrial DNA (mtDNA), have been associated with a …

Hereditary paraganglioma syndrome has recently been shown to be caused by germline
heterozygous mutations in three (SDHB, SDHC, and SDHD) of the four genes that encode …

To study the genetic basis of tumor progression, we have screened 37 hormone-refractory
prostate carcinomas for genetic changes by comparative genomic hybridization (CGH). All …

Receptor tyrosine kinase aberrations are implicated in the genesis of gliomas. We
investigated expression and amplification of KIT, PDGFRA, VEGFR2, and EGFR in 87 …

KIT, platelet‐derived growth factor receptors (PDGFRs) and vascular endothelial growth
factor receptors (VEGFRs) are important clinical targets for tyrosine kinase inhibitors. The …

Purpose Mutated KIT and platelet-derived growth factor receptor alpha (PDGFRα) tyrosine
kinases are the principal targets for imatinib mesylate in the treatment of gastrointestinal …

EGFR and erbB-2 are targets for specific cancer therapy. The purpose of this study was to
examine the frequency and clinicopathological correlations of gene amplification, protein …

Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the
digestive tract, are believed to arise from the interstitial cells of Cajal. GISTs are …

Amplification at the long arm of chromosome 8 occurs in a large fraction of breast and
prostate cancers. To clone the target genes for this amplification, we used suppression …

Gain of the long arm of chromosome 8 (8q) is one of the most common gains found in the
advanced prostate cancer by comparative genomic hybridization. We have previously …