Familial gastric cancer: overview and guidelines for management

…, ER Maher, SA Gayther, C Oliveira, N Grehan… - Journal of medical …, 1999 - jmg.bmj.com
Families with autosomal dominant inherited predisposition to gastric cancer have been
described. More recently, germline E-cadherin/CDH1 mutations have been identified in …

Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria

…, G Suriano, S Leach, J Senz, N Grehan… - Journal of medical …, 2004 - jmg.bmj.com
Background: Mutations in the E-cadherin (CDH1) gene are a well documented cause of
hereditary diffuse gastric cancer (HDGC). Development of evidence based guidelines for …

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

…, M O'donovan, TJ Underwood, AP May, N Grehan… - Nature …, 2014 - nature.com
Cancer genome sequencing studies have identified numerous driver genes, but the relative
timing of mutations in carcinogenesis remains unclear. The gradual progression from …

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

…, G Contino, J Bornschein, S MacRae, N Grehan… - Nature …, 2016 - nature.com
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have
thus far been disappointing owing to a lack of robust stratification methods. Whole-genome …

Identification of Germ-Line E-cadherin Mutations in Gastric Cancer Families of European Origin

…, SJ Ramus, D Huntsman, F Roviello, N Grehan… - Cancer research, 1998 - AACR
E-cadherin germ-line mutations have recently been described as a molecular basis for early-
onset familial gastric cancer in Maori kindred. We screened 18 gastric cancer families of …

Mechanisms and sequelae of E‐cadherin silencing in hereditary diffuse gastric cancer

…, F Carneiro, AL Paterson, N Grehan… - The Journal of …, 2008 - Wiley Online Library
Abstract Around 25–40% of cases of hereditary diffuse gastric cancer (HDGC) are caused by
heterozygous E‐cadherin (CDH1) germline mutations. The mechanisms for loss of the …

[HTML][HTML] Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

…, L Bower, A Grantham, S MacRae, N Grehan… - Nature …, 2018 - nature.com
Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates
remain less than 15%. A lack of experimental models has hampered progress. We have …

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

…, EA Bruyneel, N Moguilevsky, N Grehan… - Human molecular …, 2003 - academic.oup.com
E-cadherin is involved in the formation of cell-junctions and the maintenance of epithelial
integrity. Direct evidence of E-cadherin mutations triggering tumorigenesis has come from …

The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic

…, L Bower, G Devonshire, E Ococks, N Grehan… - Nature …, 2019 - nature.com
Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising
incidence. Understanding of the genetic events driving EAC development is limited, and …

Screening E‐cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred

C Oliveira, MC Bordin, N Grehan, D Huntsman… - Human …, 2002 - Wiley Online Library
Abstract The International Gastric Cancer Linkage Consortium (IGCLC) predicted that up to
25% of families fulfilling the criteria for hereditary diffuse gastric cancer (HDGC) would …