Purpose To summarize the global predicting role of systemic inflammatory response for
survival in renal cell carcinoma. Methods Eligible studies were identified and assessed for …

Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and,
despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive …

Retinitis pigmentosa (RP) is the most frequent form of inherited retinal dystrophy. RP is
genetically heterogeneous and the genes identified to date encode proteins involved in a …

Purpose.: Familial exudative vitreoretinopathy (FEVR) is a developmental disease that can
cause visual impairment and retinal detachment at a young age. Four genes involved in the …

Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP) are two genetically
heterogeneous retinal degenerative disorders. Despite the identification of a number of …

Pre-mRNA splicing factors play a fundamental role in regulating transcript diversity both
temporally and spatially. Genetic defects in several spliceosome components have been …

Malformations of cortical development (MCD) are neurological conditions involving focal
disruptions of cortical architecture and cellular organization that arise during …

Abstract LSD2/AOF1/KDM1b catalyzes demethylation of mono-and di-methylated H3K4 and
plays an important role in transcriptional regulation and genomic imprinting. Here, we report …

Coupling bisulfite conversion with next-generation sequencing (Bisulfite-seq) enables
genome-wide measurement of DNA methylation, but poses unique challenges for mapping …

Bulk and single-cell RNA sequencing do not provide full characterization of tissue spatial
diversity in cancer samples, and currently available in situ techniques (multiplex …