The term sarcopenia was introduced in 1988. The original definition was a “muscle loss” of
the appendicular muscle mass in the older people as measured by dual energy x‐ray …

The purpose of this statement is to provide consensus-based recommendations for optimal
management and care for patients with primary mitochondrial disease. This statement is …

Mitochondrial diseases are some of the most common inherited neurometabolic disorders,
and major progress has been made in our understanding, diagnosis, and treatment of these …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …

Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are
currently not accurately known and odds ratios alone are insufficient to assess these risks …

Evidence suggests that mitochondrial dysfunction is prominent in Alzheimer's disease (AD).
A failure of one or more of the mitochondrial electron transport chain enzymes or of F1F0 …

A previous study in proximal myotonic myopathy (PROMM/DM-2) and myotonic dystrophy
type 1 (DM-1) using brain positron emission tomography demonstrated a reduced cerebral …

Several initiatives at establishing a classification of inherited metabolic disorders have been
published previously, some focusing on pathomechanisms, others on clinical …