The distal portion of chromosome 1p is one of the most commonly affected regions in human
cancer. In this study of hereditary and sporadic colorectal cancer, a region of frequent …

A set of 90 nonpolypotic colon cancer families in which germ-line mutations of MSH2 and
MLH1 had been excluded were screened for mutations in two additional DNA mismatch …

The PH domain leucine-rich repeat protein phosphatase, PHLPP, plays a central role in
controlling the amplitude of growth factor signaling by directly dephosphorylating and …

Mouse models lacking proteins essential for autophagosome formation have demonstrated
that autophagy plays a critical role in T cell development and activation. To better …

Editor—Endometrial cancer (EC) is the second most common malignancy in the hereditary
non-polyposis colorectal cancer (HNPCC) syndrome. 1 In a recent large study, cumulative …

Since 1977, the US Supreme Court has limited the types of plaintiffs who may bring price-
fixing claims under the Sherman Act and Clayton Act. In Illinois Brick Company v. Illinois, 1 …

Perturbations of the coding genome and their role in cancer development have been studied
extensively. However the non‐coding genome's contribution is poorly understood, due to not …