Pluripotency redux—advances in stem-cell research

J Gearhart, EE Pashos, MK Prasad - New England Journal of …, 2007 - Mass Medical Soc
Deciphering the molecular basis of pluripotency will facilitate the development of procedures
for efficiently deriving patient-specific stem cells. Dr. John Gearhart, Evanthia Pashos, and …

A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement

MK Prasad, V Geoffroy, S Vicaire, B Jost… - Journal of medical …, 2016 - jmg.bmj.com
Background Orodental diseases include several clinically and genetically heterogeneous
disorders that can present in isolation or as part of a genetic syndrome. Due to the vast …

[HTML][HTML] Identification of a novel mutation confirms the implication of IFT172 (BBS20) in Bardet–Biedl syndrome

E Schaefer, C Stoetzel, S Scheidecker… - Journal of human …, 2016 - nature.com
Abstract Bardet–Biedl syndrome (BBS; MIM 209900) is a recessive heterogeneous
ciliopathy characterized by retinitis pigmentosa (RP), postaxial polydactyly, obesity …

Insights into ciliary genes and evolution from multi-level phylogenetic profiling

Y Nevers, MK Prasad, L Poidevin… - Molecular biology …, 2017 - academic.oup.com
Cilia (flagella) are important eukaryotic organelles, present in the Last Eukaryotic Common
Ancestor, and are involved in cell motility and integration of extracellular signals. Ciliary …

Gpnmb is a melanoblast‐expressed, MITF‐dependent gene

SK Loftus, A Antonellis, I Matera… - Pigment cell & …, 2009 - Wiley Online Library
Expression profile analysis clusters Gpnmb with known pigment genes, Tyrp1, Dct, and Si.
During development, Gpnmb is expressed in a pattern similar to Mitf, Dct and Si with …

[HTML][HTML] SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer

MK Prasad, X Reed, DU Gorkin, JC Cronin… - BMC developmental …, 2011 - Springer
Background The ERBB3 gene is essential for the proper development of the neural crest
(NC) and its derivative populations such as Schwann cells. As with all cell fate decisions …

Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta

M Huckert, C Stoetzel, S Morkmued… - Human molecular …, 2015 - academic.oup.com
Inherited dental malformations constitute a clinically and genetically heterogeneous group of
disorders. Here, we report on four families, three of them consanguineous, with an identical …

[HTML][HTML] Beyond the promise: evaluating and mitigating off-target effects in CRISPR gene editing for safer therapeutics

R Lopes, MK Prasad - Frontiers in Bioengineering and …, 2023 - ncbi.nlm.nih.gov
Over the last decade, CRISPR has revolutionized drug development due to its potential to
cure genetic diseases that currently do not have any treatment. CRISPR was adapted from …

Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing

MV Harden, L Pereiro, M Ramialison… - Developmental …, 2012 - Wiley Online Library
Vertebrate sensory organs originate from both cranial neural crest cells (CNCCs) and
placodes. Previously, we have shown that the olfactory placode (OP) forms from a large field …

[HTML][HTML] A Polymorphic 3'UTR Element in ATP1B1 Regulates Alternative Polyadenylation and Is Associated with Blood Pressure

MK Prasad, K Bhalla, ZH Pan, JR O'Connell… - PLoS …, 2013 - journals.plos.org
Although variants in many genes have previously been shown to be associated with blood
pressure (BP) levels, the molecular mechanism underlying these associations are mostly …