Cellular stress response is a universal mechanism that ensures the survival or negative
selection of cells in challenging conditions. The transcription factor Forkhead box protein O3 …

Colorectal cancer (CRC) is one of the deadliest forms of cancer worldwide. CRC
development occurs mainly through the adenoma-carcinoma sequence, which can last …

An altered metabolism is involved in the development of clear cell-renal cell carcinoma
(ccRCC), and in this tumor many altered genes play a fundamental role in controlling cell …

Lynch syndrome is a hereditary cancer-predisposing syndrome caused by germline defects
in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. Carriers of …

The HSF and FOXO families of transcription factors play evolutionarily conserved roles in
stress resistance and lifespan. In humans, the rs2802292 G-allele at FOXO3 locus has been …

Simple Summary Colorectal cancer (CRC) is the most common gastrointestinal tract
malignancy. Previous reports have shown that cancerous phenotypes in the intestine are …

For many years, inversions have been proposed to be a direct driving force in speciation
since they suppress recombination when heterozygous. Inversions are the most common …

While aberrant cancer cell growth is frequently associated with altered biochemical
metabolism, normal mitochondrial functions are usually preserved and necessary for full …

The prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This
is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination …

Colorectal cancer (CRC) poses a formidable challenge in terms of molecular heterogeneity,
as it involves a variety of cancer-related pathways and molecular changes unique to an …