Gene expression profiles and chromosome 3 copy number divide uveal melanomas into two
distinct classes correlating with prognosis,,. Using exome sequencing, we identified …

Uveal melanoma is the most common intraocular malignancy. About 50% of patients die of
metastases, which almost exclusively originate from primary tumors that have lost one …

Background: A growing body of evidence supports the hypotheses that the retinoic acid
receptor β2 (RAR-β2) gene is a tumor suppressor gene and that the chemopreventive …

Chromatin remodeling complexes are known to modify chemical marks on histones or to
induce conformational changes in the chromatin in order to regulate transcription. De novo …

Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ
secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro …

The analysis of allelic methylation differences in 15ql 1-ql 3 has been established as a valid
test for the Angelman and Prader-Willi syndromes. Current tests use methylation-sensitive …

Background Recent years have seen major changes in the diagnosis and treatment of solid
intraocular tumors, mainly owing to an improved molecular biological understanding of their …

Uveal melanoma (UM), a tumor of the eye, can be divided into 2 major classes correlating
with patients' prognosis. Gene expression profiles and chromosome 3 status are correlated …

Altered methylation patterns have been found to play a role in developmental disorders,
cancer and aging. Increasingly, changes in DNA methylation are used as molecular markers …

Cadherins are a gene family encoding calcium-dependent cell adhesion proteins which are
thought to act in the establishment and maintenance of tissue organization. M-cadherin, one …