Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs …

Genetic association studies have identified 215 risk loci for inflammatory bowel disease,,,,,,,,
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …

Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a
previously unknown susceptibility locus at ECM1. We also show that several risk loci are …

Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …

BACKGROUND & AIMS: Identifying shared and disease-specific susceptibility loci for
Crohn's disease (CD) and ulcerative colitis (UC) would help define the biologic relationship …

Background & Aims: Identification of inflammatory bowel disease (IBD) susceptibility genes
is key to understanding pathogenic mechanisms. Recently, the North American IBD …

Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine
or mercaptopurine. Its development is unpredictable and almost always leads to drug …