Alzheimer's disease is one of the most common causes of mental deterioration in elderly
people, accounting for around 50%-60% of the overall cases of dementia among persons …

Background Respiratory syncytial virus (RSV) is the most common cause of acute lower
respiratory infection in young children. We previously estimated that in 2015, 33· 1 million …

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of
the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that …

Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

Background A safe and efficacious vaccine against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control …

Background Older adults (aged≥ 70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …

Summary Background The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for
emergency use by the UK regulatory authority, Medicines and Healthcare products …

Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection …

Background A new variant of SARS-CoV-2, B. 1.1. 7, emerged as the dominant cause of
COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the …

Background Use of heterologous prime-boost COVID-19 vaccine schedules could facilitate
mass COVID-19 immunisation. However, we have previously reported that heterologous …