Abstract Cancer survivors constitute 3.5% of the United States population, but second
primary malignancies among this high-risk group now account for 16% of all cancer …

Some details are inevitably lost when attempting to simplify subjects involving complex
medical genetics subjects. However, unless an attempt is made to distill such topics, busy …

Familial aggregations of testicular germ cell tumor (FTGCT) have been well described,
suggesting the existence of a hereditary TGCT subset. Approximately 1.4% of newly …

Six evident lesional steps of tumor progression form the neoplastic system that affects the
human epidermal melanocyte: 1) the common acquired melanocytic nevus; 2) a melanocytic …

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Objective Etanercept and infliximab are tumor necrosis factor (TNF) antagonists that have
been recently approved for the treatment of rheumatoid arthritis (RA) and Crohn's disease …

The risk of hereditary cutaneous malignant melanoma was evaluated in 401 members of 14
families with an autosomal dominant form of melanoma. We documented 127 primary …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

Fanconi anemia (FA) is an autosomal recessive condition associated with congenital
abnormalities, progressive pancytopenia, and a predisposition to leukemia and solid tumors …