Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …

'Aging epigenetics' is an emerging field that promises exciting revelations in the near future.
Here we focus on the functional and biological significance of the epigenetic alterations that …

Ever since methylcytosine was found in genomic DNA, this epigenetic alteration has
become a center of scientific attraction, especially because of its relation to gene silencing in …

Monozygous twins share a common genotype. However, most monozygotic twin pairs are
not identical; several types of phenotypic discordance may be observed, such as differences …

Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic
acids. They are secreted by all cells and circulate in the blood. Specific detection and …

CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …

The mechanisms underlying microRNA (miRNA) disruption in human disease are poorly
understood. In cancer cells, the transcriptional silencing of tumor suppressor genes by CpG …

Transcriptional repression mechanisms have emerged as one of the crucial processes for
the downregulation of E-cadherin expression during development and tumour progression …

Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …

Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …