User profiles for "author:M Esteller"
Manel EstellerDirector, Josep Carreras Leukaemia Research Institute. University of Barcelona and ICREA Verified email at carrerasresearch.org Cited by 143115 |
Non-coding RNAs in human disease
M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …
context of the widespread disruption of microRNA (miRNA) expression and function that is …
Epigenetics in cancer
M Esteller - New England Journal of Medicine, 2008 - Mass Medical Soc
Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
DNA methylation and cancer
M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …
In normal cells, it assures the proper regulation of gene expression and stable gene …
Epigenetic differences arise during the lifetime of monozygotic twins
…, YZ Wu, C Plass, M Esteller - Proceedings of the …, 2005 - National Acad Sciences
Monozygous twins share a common genotype. However, most monozygotic twin pairs are
not identical; several types of phenotypic discordance may be observed, such as differences …
not identical; several types of phenotypic discordance may be observed, such as differences …
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …
features of cancer cells. Less attention has been focused on histone modifications in cancer …
The Polycomb group protein EZH2 directly controls DNA methylation
…, D Bernard, JM Vanderwinden, M Bollen, M Esteller… - Nature, 2006 - nature.com
The establishment and maintenance of epigenetic gene silencing is fundamental to cell
determination and function. The essential epigenetic systems involved in heritable …
determination and function. The essential epigenetic systems involved in heritable …
Global epigenomic reconfiguration during mammalian brain development
Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …
during brain development, maturation, and learning. DNA methylation (mC) is a stable …
[HTML][HTML] Gene-expression profiles in hereditary breast cancer
…, P Meltzer, B Gusterson, M Esteller… - … England Journal of …, 2001 - Mass Medical Soc
Background Many cases of hereditary breast cancer are due to mutations in either the
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …
[PDF][PDF] A landscape of pharmacogenomic interactions in cancer
…, N Lopez-Bigas, P Ross-Macdonald, M Esteller… - Cell, 2016 - cell.com
Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application …
molecular nature of cancer. Using this information to guide the development and application …
A microRNA DNA methylation signature for human cancer metastasis
…, SA Eccles, CM Croce, M Esteller - Proceedings of the …, 2008 - National Acad Sciences
MicroRNAs (miRNAs) are small, noncoding RNAs that can contribute to cancer development
and progression by acting as oncogenes or tumor suppressor genes. Recent studies have …
and progression by acting as oncogenes or tumor suppressor genes. Recent studies have …