Age-related hearing impairment (ARHI) is the most common sensory impairment seen in the
elderly. It is a complex disorder, with both environmental as well as genetic factors …

Many different heritable connective tissue disorders (HCTD) have been described over the
past decades. These syndromes often affect the connective tissue of various organ systems …

Aortic aneurysm, including both abdominal aortic aneurysm and thoracic aortic aneurysm, is
the cause of death of 1% to 2% of the Western population. This review focuses only on …

Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth
factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding …

Nonsyndromic hearing impairment is one of the most heterogeneous hereditary conditions,
with more than 40 loci mapped on the human genome 1, however, only a limited number of …

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia
bundles of specialized sensory hair cells. Sound induces movement of these hair cells …

A multicenter study was set up to elucidate the environmental and medical risk factors
contributing to age-related hearing impairment (ARHI). Nine subsamples, collected by nine …

Auditory neuropathy is a particular type of hearing impairment in which neural transmission
of the auditory signal is impaired, while cochlear outer hair cells remain functional. Here we …

We have determined the molecular basis for Usher syndrome type 1F (USH1F) in two
families segregating for this type of syndromic deafness. By fluorescence in situ …

Background: Aneurysms affecting the aorta are a common condition associated with high
mortality as a result of aortic dissection or rupture. Investigations of the pathogenic …