User profiles for "author:L Luzzatto"
Lucio LuzzattoScientific Director, Istituto Toscano Tumori, Florence, ITALY Verified email at ittumori.it Cited by 31504 |
Diagnosis and management of paroxysmal nocturnal hemoglobinuria
The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are
hemolytic anemia, marrow failure, and thrombophilia. However, PNH is not a simple binary …
hemolytic anemia, marrow failure, and thrombophilia. However, PNH is not a simple binary …
Glucose-6-phosphate dehydrogenase deficiency
G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
[HTML][HTML] COVID-19 2022 update: transition of the pandemic to the endemic phase
…, VL Colona, R Mehrian-Shai, JL Watt, L Luzzatto… - Human genomics, 2022 - Springer
COVID-19, which is caused by the SARS-CoV-2, has ravaged the world for the past 2 years.
Here, we review the current state of research into the disease with focus on its history …
Here, we review the current state of research into the disease with focus on its history …
[HTML][HTML] The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
…, CF Mojcik, RP Rother, L Luzzatto - … England Journal of …, 2006 - Mass Medical Soc
Background We tested the safety and efficacy of eculizumab, a humanized monoclonal
antibody against terminal complement protein C5 that inhibits terminal complement …
antibody against terminal complement protein C5 that inhibits terminal complement …
[HTML][HTML] Natural history of paroxysmal nocturnal hemoglobinuria
…, SM Lewis, M Bessler, L Luzzatto… - New England Journal …, 1995 - Mass Medical Soc
Background Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by
intravascular hemolysis and venous thrombosis, is an acquired clonal disorder associated …
intravascular hemolysis and venous thrombosis, is an acquired clonal disorder associated …
Targeted disruption of the housekeeping gene encoding glucose 6‐phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for …
Glucose 6‐phosphate dehydrogenase (G6PD) is a housekeeping enzyme encoded in
mammals by an X‐linked gene. It has important functions in intermediary metabolism …
mammals by an X‐linked gene. It has important functions in intermediary metabolism …
Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria
…, AM Risitano, J Schubert, L Luzzatto… - Blood, The Journal …, 2007 - ashpublications.org
Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic
disorders. In paroxysmal nocturnal hemoglobinuria (PNH) patients, hemolysis can contribute …
disorders. In paroxysmal nocturnal hemoglobinuria (PNH) patients, hemolysis can contribute …
Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
The stable introduction of a functional β-globin gene in haematopoietic stem cells could be a
powerful approach to treat β-thalassaemia and sickle-cell disease. Genetic approaches …
powerful approach to treat β-thalassaemia and sickle-cell disease. Genetic approaches …
Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG‐A gene.
…, T Miyata, N Yamada, J Takeda, L Luzzatto… - The EMBO …, 1994 - embopress.org
Paroxysmal nocturnal haemoglobinuria (PNH), an acquired clonal blood disorder, is caused
by the absence of glycosyl phosphatidylinositol (GPI)‐anchored surface proteins due to a …
by the absence of glycosyl phosphatidylinositol (GPI)‐anchored surface proteins due to a …
[PDF][PDF] Glucose-6-phosphate dehydrogenase deficiency
L Luzzatto, A Mehta, T Vulliamy - The metabolic and molecular …, 2001 - thebloodproject.com
G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …